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. 2014 Jan 23;42(7):4406–4413. doi: 10.1093/nar/gkt1412

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© The Author(s) 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Sequestration of Rpa by HU-induced replicative stress results in its unavailability for NER. MEF lines of each genotype were mock treated (left panels) or globally exposed to 2 mM HU (right panels) to induce the arrest of replication forks, followed by local UV-C treatment. Then, cells were stained for CPD (green), Rpa (yellow), EdU (red) and for nuclei (blue). Irrespective of the Rev3 status, Rpa is hardly recruited to local UV damage in the presence of replication forks, arrested by HU.