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Replication of WT and dinucleotide-modified viruses in an IRF3-blocked cell line. A549 cells expressing the viral protein Npro and non-expressing control cells were infected with WT, C|C (R1/R2 CpG-high) and U|U (R1/R2 UpA-high) at an MOI of 0.01. RNA was extracted from cell culture supernatant at 24 h and viral load determined by qRT-PCR. Results are the mean and standard error of three biological replicates.
