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Fitness determination by competition assays between WT and modified viruses. RD cells were infected with an equal MOI of WT and modified virus, and the supernatant serially passaged through cells. RNA was isolated and the composition of each virus determined through selective restriction digests. Images show the virus composition in the starting inoculum and in three biological replicates following passage of CpG- and UpA-low mutants and of U|W.
