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. 2014 Jan 31;42(7):4208–4219. doi: 10.1093/nar/gku102

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© The Author(s) 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Examples of linked modules in the yeast module map. The genes of each module are arranged in a circle. Blue edges represent negative GIs and pink edges represent PPIs. For each module, the most enriched GO term is shown along with its enrichment P-value. (A) Linkage among different protein complexes. The significance of the links between Rpd3L and the Set3 complexes and between Swr1 and Rpd3L complexes is <10E-70. The link between Swr1 and Set3 is also highly significant (P = 4.29E-59). (B) Detection of subcomplexes. The joint analysis of the PPI and GI networks partitions the proteasome complex into its two subcomplexes: the accessory and the core complex.