Changes in ThT fluorescence at 483 nm over time
in the absence
(black) and presence of Cu(II) (green), Zn(II) (blue), and Ni(II)
(red). Each solution contained 100 μM β2m, 150 μM
CuSO4 or ZnSO4 or 3 mM NiSO4, 500
mM urea, 150 mM potassium acetate, 25 mM MOPS (pH 7.4), and 80 μM
ThT.