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(a) Structural changes of β2m upon Cu(II) binding, including repositioning of Arg3 and Asp59 and exposure of Phe30 to the solvent followed by cis–trans isomerization of Pro32 (the β2m backbone is colored green; repositioning of the residues is indicated from blue to magenta). (b) Proposed model for the different effects of Cu(II), Ni(II), and Zn(II) on β2m oligomerization and fibril formation.
