Table 2. Pharmacokinetic Parameters of Oxadiazoles^a.

cmpd	dose (mg/kg)	AUC0–∞ (μg·min/mL)	Cmax (μg/mL)	Tmax (h)	CL (mL/min/kg)	Vd (mL/kg)	t1/2	F (%)
2	50 iv	1380			36.2	860	t1/2α = 2.4 min
							t1/2β = 4.4 h
3	50 iv	2650			18.9	370	t1/2α = 3.5 min
							t1/2β = 22 h
	50 po	2620	2.5	2			t1/2abs = 3.3 h	∼100
							t1/2dist = 6.0 h
							t1/2elim = 40 h
4	50 iv	9200			5.4	720	t1/2α = 6.7 min
							t1/2β = 20 h
	50 po	9220	10.0	2			t1/2abs = 2.4 h	100
							t1/2dist = 13 h
							t1/2elim = 36 h

^an = 3 mice per time point per route of administration; 10–12 time points. AUC_0–∞, area under the plasma concentration–time curve from 0 to infinity; C_max, maximum concentration observed in plasma; T_max, time at which maximum plasma concentration is observed; CL, plasma clearance; V_d, volume of distribution; t_1/2α, initial half-life; t_1/2β, terminal half-life; t_1/2abs, absorption half-life; t_1/2dist, distribution half-life; t_1/2elim, elimination half-life; F, oral bioavailability.