Table 2. Binding Energies for Selected, Optimized Peptide Sequences.

^aUsing the search algorithm, peptide sequence candidates are evolved on the basis of a backbone scaffold of structure. For each binding structure, an explicit binding energy is generated. This search and selection process does not quantify the error in the binding energy.

^bPeptides are numbered in accordance with the previous report of phage display selected sequences.⁹ P6 is from the original selection, and P26–P38 were chosen based on predictions in silico. P35* with the sequence RWNHCQFWSGWRANG has a single amino acid serine change from P35. Peptide sequences A and B from cases 2 and 3, respectively, were not selected for chemical synthesis and analysis.