Figure 1.

Comparison between experimental ΔΔG_exp and predicted changes in binding affinity ΔΔG. Training is performed on SKEMPI single (A, B) and multiple (C, D) mutation sets. A: Testing on SKEMPI single mutation set. B: Testing on NM single mutation set. C: Testing on SKEMPI multiple mutation set. D: Testing on NM multiple mutation set. N_mut is the number of mutations in the dataset. R is the Pearson correlation coefficient between experimental and predicted ΔΔG values. All correlation coefficients were significantly different from zero with p-values ≪0.01.