Figure. 2.

Schematic of a crawling cell on a 2D substrate to show the most prominent locations for the three types of cytoskeleton biopolymers. MTs are typically nucleated at the centrosome and span most parts of the cell. IFs are most commonly around the cell nucleus whereas actin filaments form dense networks close to the cell membrane. Particularly dense and dynamic actin networks are found at the leading edge of migrating cells (forming lamellipodia and filopodia).