Figure. 32.

Model picture of the self-organizing actin network within lamellipodia. ATP-hydrolysis acts as a timer mechanism resulting in distinguishable zones dominated by different actin accessory proteins. Branching and hence nucleation of new filaments is driven by Arp2/3 at the front while in the middle zone debranching and depolymerization dominate. At the rear of the network filaments, start to be hindered from fast depolymerization by tropomyosin binding. Illustration was taken from [57] with permission of Marie-France Carlier.