Table 2.

Overview and classification of different models aiming at describing crawling, lamellipodia-based cell migration.

Modeling approach	Scope	Modeled levels of complexity	Examples
All protein models (stochastic-discrete)	Lamellipodium (+lamellum)		[180,393,409–411]
Microscopic mean-field models (deterministic-continuous)	Lamellipodium (+lamellum)		[179,412]
	Whole cell		[413–415]
Filament-based models (stochastic-discrete)	Lamellipodium (+lamellum)		[416]
Macroscopic/hydrodynamic models (deterministic-continuous)	Lamellipodium (+lamellum)		[417]
	Whole cell		[418,419]

Notes: The models are classified according to their modeling scope and their different inherent hierarchical reductions (Section 1.2.1). Red encircled scales represent the levels of complexity covered by the respective models. Feedback loops, i.e. arrows pointing from higher to lower levels, are not drawn explicitly.