Membrane-encapsulated
QDs functionalized with DNA-AuNP. QD-DOPC
vesicles were incubated with SH-DNA and hybridized with complementary
DNA-AuNP, and then imaged using PL microscopy (a, QD), darkfield scattering
microscopy (b, AuNP), and then overlaid to show colocalization (c).
When this sample was treated with DI water, the QD emission was no
longer localized with AuNP darkfield scattering (e–g), indicating
dehybridization of double-stranded DNA and disassembly of QD-DNA-AuNP
structures. (d) and (h) show the models for assembly and disassembly
of QD-DNA-AuNP hybrid structures.