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Synthesis of halogenated β,γ-dTTP and dCTP analogues. (a) 2d–3d: NaH, Selectfluor/THF/DMF, −42 °C; 5d: NaOCl, 0 °C; 4d (from 5d): Na2SO3/H2O/EtOH, 0 °C; 7d: Br2, NaOH/H2O, 0 °C; 6d: (from 7d): SnCl2/H2O/EtOH, 0 °C; 8d (from 4d): NaH, Selectfluor/THF/DMF, −42 °C; (b) 1e–4e and 8e: HCl reflux; 6e and 7e: HBr, reflux.
