TABLE 3.
Applications of the DLW method in the CALERIE clinical trial among study participants who were randomly assigned to the caloric restriction intervention1
| Nutrition applications | Mean values |
| CR prescription | |
| EIAL, kcal·d−1 | 2467 ± 443 (1883–3225) |
| Prescription, kcal·d−1 | 1803 ± 325 (1400–2346) |
| Adherence monitoring (baseline to 6 mo) | |
| Prescription, kcal·d−1 | 1803 ± 325 (1400–2346) |
| EIP, kcal·d−1 | 1696 ± 341 (1254–2393) |
| ΔES, kcal·d−1 | −363 ± 126 (−614 to −219) |
| EIAL, kcal·d−1 | 2467 ± 443 (1883–3225) |
| %CR, % | 31 ± 5 (25–38) |
| Body compositional changes (baseline to 6 mo) | |
| NO at baseline, kg | 36.2 ± 7.8 (26.1–48.0) |
| TBW at baseline, kg | 35.8 ± 7.7 (25.9–47.6) |
| FFM at baseline, kg | 49.1 ± 10.6 (35.4–65.2) |
| FM at baseline, kg | 26.5 ± 5.9 (19.0–34.4) |
| ΔNO, kg | −0.8 ± 1.1 (−2.5–0.8) |
| ΔFFM, kg | −1.0 ± 1.5 (−3.3–1.0) |
| ΔFM, kg | −8.6 ± 3.4 (−15.2 to −4.6) |
1
Values are means ± SDs (ranges), n = 10. CALERIE, Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy; CR, caloric restriction; DLW, doubly labeled water; EIAL, ad libitum energy intake; EIp, energy intake over the period of interest; FM, fat mass; FFM, fat-free mass; NO, isotope dilution space of 18O; TBW, total body water; %CR, percentage of CR achieved; ΔES, change in body energy stores; ΔFM, change in FM; ΔFFM, change in FFM; ΔNO, change in the isotope dilution space of 18O.