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Quinolone structures. Nalidixic acid and oxolinic acid were the first-generation quinolones that were used most often in the clinic. Norfloxacin, ciprofloxacin, and ofloxacin are the most relevant second-generation quinolones. Levofloxacin (the levorotary isomer of ofloxacin), sparfloxacin, and moxifloxacin are newer-generation quinolones.
