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A model, from an X-ray crystal structure, of the complex between TIM from yeast and DHAP (PDB entry 1NEY) showing the amino acids mutated in this work. The side chains of H95, K12, and N10 play key roles in catalysis of the isomerization reaction.2,3Small differences in the numbering of the amino acids at TIM from the different sources used in these studies are noted, where appropriate: (cTIM or yTIM and TbbTIM): Pro 166 and 168, I170 and 172, L230 and 232.
