Table 3. Analysis of the Kinetics of Single-Turnover MgATP Cleavage Reactions in Wild-Type and Mutant RePC.
enzyme | Kd (μM) | kcat (s–1) | kcat (% of WT value) |
---|---|---|---|
WT | 10 ± 4 | 1.400 ± 0.004 | 100 |
H216N | 12 ± 2 | 0.011 ± 0.001 | 0.8 |
E218Q | 11 ± 3 | 0.032 ± 0.003 | 2.2 |
E305A | 8 ± 5 | 0.032 ± 0.010 | 2.2 |