Figure 5.

Interpretation of cross-linking data according to the crystal structure of the CCR5–maraviroc complex (Protein Data Bank entry 4MBS).²⁹ Ribbon diagram of CCR5 as viewed from the extracellular surface of the receptor with the N-terminus colored blue, fading to red at the C-terminus. Maraviroc and disulfide-linked Cys residues are shown as sticks (cyan carbons). Surface representation of CCR5 with residues cross-linked to 2D7 (middle) and PRO 140 (bottom) colored red fading to green. Residues substituted with azF are numbered in white. The color bar indicates the range of relative cross-linking signals from non-cross-linked sites (green) to cross-linked sites (red). The blue surface corresponds to residues not tested in this study. Molecular graphics were prepared with VMD version 1.9.1.⁶⁶