Disintegration
time (tc) hydrogels
prepared from 4-armPEG-N3 with varying ratios of 4-armPEG-ester-DBCO
and 4-armPEG-amide-DBCO (r) predicted by the theoretical
model and validated by experimental data. (A,B) Prediction curves
of the intact linkage fraction P vs time in PBS (pH
7.4) and α-MEM, respectively. The red dotted line represents
the critical intact linkage fraction of the network (Pc = 1/3), and its crosspoint with each curve indicates
the predicted tc for the specific formulation.
(C,D) Predicted (blue) and experimentally observed (red) tc in PBS (pH 7.4) and α-MEM, respectively.