Disintegration times (tc) of hydrogels
prepared from 4-armPEG-amide-DBCO with varying ratios of 4-armPEG-ester-N3 and 4-armPEG-N3 (r) predicted
by the theoretical model and validated by experimental data. (A,B)
Prediction curves of the intact linkage fraction P vs time in PBS (pH 7.4) and α-MEM, respectively. The red dotted
line represents the critical intact linkage fraction of the network
(Pc = 1/3), and its crosspoint with each
curve indicates the predicted tc for the
specific formulation. (C,D) Predicted (blue) and experimentally observed
(red) tc in PBS (pH 7.4) and α-MEM,
respectively.