Table 2.
Results of multivariable analysis for the effect of an increase in opposite-sex household antiretroviral therapy coverage on HIV seroconversion hazard
|
Opposite-sex model |
Full model |
||||
|---|---|---|---|---|---|
| Adjusted hazard ratio (95% CI) | p value | Adjusted hazard ratio (95% CI) | p value | ||
| Opposite-sex antiretroviral therapy coverage* | 0·94 (0·91–0·98) | 0·0036 | 0·94 (0·91–0·98) | 0·0034 | |
| Opposite-sex HIV prevalence† | 1·05 (1·03–1·07) | <0·0001 | 1·05 (1·03–1·07) | <0·0001 | |
| Number of opposite-sex coresidents‡ | 0·98 (0·96–1·02) | 0·4072 | 0·98 (0·95–1·02) | 0·3292 | |
| Knows HIV status | |||||
| Yes (reference) | 1·00 | .. | 1·00 | .. | |
| No | 1·11 (0·99–1·25) | 0·0705 | 1·11 (0·99–1·25) | 0·0695 | |
| Refused | 1·30 (0·60–2·80) | 0·5004 | 1·30 (0·60–2·79) | 0·5027 | |
| Has heard about antiretroviral therapy | |||||
| Yes (reference) | 1·00 | .. | 1·00 | .. | |
| No | 0·98 (0·88–1·10) | 0·7476 | 0·98 (0·88–1·10) | 0·7846 | |
| Refused | 0·70 (0·33–1·49) | 0·3592 | 0·70 (0·33–1·50) | 0·3616 | |
| Age-sex stratum | |||||
| Men aged 15–19 years (reference) | 1·00 | .. | 1·00 | .. | |
| Men aged 20–24 years | 3·76 (2·87–4·93) | <0·0001 | 3·77 (2·87–4·94) | <0·0001 | |
| Men aged 25–29 years | 5·36 (3·95–7·26) | <0·0001 | 5·36 (3·95–7·27) | <0·0001 | |
| Men aged 30–34 years | 3·72 (2·47–5·59) | <0·0001 | 3·70 (2·46–5·56) | <0·0001 | |
| Men aged 35–39 years | 3·38 (2·23–5·13) | <0·0001 | 3·37 (2·22–5·11) | <0·0001 | |
| Men aged 40–44 years | 2·56 (1·62–4·06) | <0·0001 | 2·55 (1·61–4·05) | <0·0001 | |
| Men aged ≥45 years | 2·01 (1·28–3·15) | 0·0023 | 2·00 (1·28–3·14) | 0·0024 | |
| Women aged 15–19 years | 5·75 (4·52–7·32) | <0·0001 | 5·75 (4·51–7·32) | <0·0001 | |
| Women aged 20–24 years | 9·59 (7·52–12·23) | <0·0001 | 9·58 (7·50–12·23) | <0·0001 | |
| Women aged 25–29 years | 8·04 (6·14–10·52) | <0·0001 | 8·03 (6·13–10·52) | <0·0001 | |
| Women aged 30–34 years | 5·11 (3·78–6·90) | <0·0001 | 5·10 (3·77–6·90) | <0·0001 | |
| Women aged 35–39 years | 3·03 (2·18–4·22) | <0·0001 | 3·03 (2·17–4·22) | <0·0001 | |
| Women aged 40–44 years | 2·63 (1·90–3·65) | <0·0001 | 2·63 (1·90–3·65) | <0·0001 | |
| Women aged ≥45 years | 1·68 (1·21–2·33) | 0·0018 | 1·68 (1·21–2·33) | 0·0018 | |
| Area of residence | |||||
| Rural (reference) | 1·00 | .. | 1·00 | .. | |
| Peri-urban | 1·29 (1·16–1·44) | <0·0001 | 1·29 (1·16–1·43) | <0·0001 | |
| Urban | 1·27 (0·97–1·67) | 0·0861 | 1·27 (0·97–1·67) | 0·0866 | |
| Household wealth quintile | |||||
| Poorest (reference) | 1·00 | .. | 1·00 | .. | |
| Second poorest | 1·04 (0·90–1·20) | 0·6883 | 1·04 (0·90–1·20) | 0·5874 | |
| Third poorest | 1·06 (0·92–1·23) | 0·4065 | 1·06 (0·92–1·23) | 0·4148 | |
| Fourth poorest | 1·14 (0·98–1·32) | 0·0848 | 1·14 (0·98–1·32) | 0·0857 | |
| Wealthiest | 0·91 (0·77–1·08) | 0·2856 | 0·91 (0·77–1·08) | 0·2843 | |
| Changes of household residencies | |||||
| None (reference) | 1·00 | .. | 1·00 | .. | |
| One | 1·15 (0·97–1·35) | 0·1075 | 1·14 (0·97–1·35) | 0·1067 | |
| Two or more | 1·26 (0·92–1·73) | 0·1437 | 1·26 (0·92–1·73) | 0·1442 | |
| Same-sex antiretroviral therapy coverage* | .. | .. | 1·03 (0·98–1·08) | 0·2974 | |
| Same-sex HIV prevalence† | .. | .. | 1·00 (0·96–1·05) | 0·8380 | |
| Number of seroconversions | 2037 | .. | 2037 | .. | |
| Number of at-risk individuals | 14 505 | .. | 14 505 | .. | |
95% CIs are based on SEs that have been adjusted for clustering at the household level.
Adjusted hazard ratio represents the change in HIV seroconversion hazard for any increase of ten percentage points in household antiretroviral therapy coverage, controlling for the other independent variables in the regression model.
Adjusted hazard ratio represents the change in HIV seroconversion hazard for any increase of ten percentage points in household HIV prevalence, controlling for the other independent variables in the regression model.
Adjusted hazard ratio represents the change in HIV seroconversion hazard for an increase in household size by one opposite-sex member, controlling for the other independent variables in the regression model.