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. Author manuscript; available in PMC: 2014 Apr 14.
Published in final edited form as: Ann Surg. 2014 Apr;259(4):793–799. doi: 10.1097/SLA.0b013e3182a6f552

FIGURE 5.

FIGURE 5

Treatment of mice with tumors confirms apoptotic effects of sunitinib (SUN). (A), Micrographs from MCF-7 xenograft tumors showing hematoxylin-eosin (H&E) staining and immunohistochemistry for Ki-67 and TUNEL. (B), Animals treated with sunitinib were significantly less likely to develop tumors than control animals. (C), Ki-67 positivity was significantly reduced by sunitinib treatment. (D), TUNEL-positive apoptotic cells were significantly increased in sunitinib-treated animals. *P < 0.05.