Table 2. Parameters and default values representing a resting cell (from [17]).

Parameter	Meaning	Default	Units
Evolutionary
λ	Mutation rate parameter	0.1	hr−1
ηi	Proliferation secretion effort of clone i	1, max = 12	min−1
	Basic TAF secretion effort of clone i	0.11	g/U/min
Energetic
αa	de novo AMP synthesis rate	5.725×10−5	fmol/min
k	Adenylate kinase rate parameter	106	1/fmol/min
β 1	Maintenance ATP to AMP rate	4	min−1
β 2	Maintenance ATP to ADP rate	4	min−1
γa	Adenosine kinase rate	0.01	min−1
μ	ATP destruction rate	0.01	min−1
ξ	Nutrient sensitivity of TAF secretion	10/3	g/U
smax	Physiological max ATP regeneration rate	390	min−1
M 1	AMP deaminase parameter	0.4	fmol/min
M 2	Nucleotidase parameter	9.167×10−7	fmol/min
k 1	AMP deaminase parameter	0.5	fmol
k 2	Nucleotidase parameter	5×10−3	fmol
k 3	Nucleotidase parameter	2.5×10−10	fmol2
k 4	Nucleotidase parameter	5×10−5	fmol
Tissue
p	Basic parenchyma proliferation rate	0.072	hr−1
ks	Proliferation sensitivity parameter	2	fmol/min
m	Parenchyma mortality parameter	0.0698	fmol/hr
α	Max VEC response to TAF	0.1	hr−1
kv	Sensitivity of VECs to TAF	0.0115	fmol/min
β	VEC death/maturation rate	0.04	hr−1
γ	VEC maturation rate	3	U/g/hr
δ	Microvessel remoldeling rate	4×10−3	g/U/hr