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. 2014 Apr 14;9(4):e94550. doi: 10.1371/journal.pone.0094550

Table 3. Genes up- or down-regulated >2.0 fold in pulmonary cells of mice at 2 and 3 weeks after CBDL, assembled by a magnetic bead/CD31-antibody complex, in comparison with levels in sham operated mice, as determined by the Gene Chip Mouse Gene 1.0 ST Array.

Gene ID Symbol Gene Name Fold change 2w 3w
17394 MMP8 matrix metallopeptidase 8 (neutrophil collagenase) 18.597 20.121
74145 F13A1 coagulation factor XIII, A1 polypeptide 12.429 7.512
20201 S100A8 S100 calcium binding protein A8 11.960 13.878
21926 TNF tumor necrosis factor 7.439 2.874
56619 CLEC4E C-type lectin domain family 4, member E 7.318 3.959
12475 CD14 CD14 molecule 7.262 4.187
13003 VCAN versican 7.093 3.964
100034251 Gm11428 predicted gene 11428 7.012 9.548
104183|12655 Chi3l3/Chi3l4 chitinase 3-like 3 6.984 3.645
20288 MSR1 macrophage scavenger receptor 1 6.929 4.557
14058 F10 coagulation factor X 6.638 3.471
12772 CCR2 chemokine (C-C motif) receptor 2 6.389 4.536
20202 S100A9 S100 calcium binding protein A9 6.283 7.824
58217 TREM1 triggering receptor expressed on myeloid cells 1 5.96 5.005
216799 NLRP3 NLR family, pyrin domain containing 3 5.68 3.363
20310 CXCL3 chemokine (C-X-C motif) ligand 3 5.531 3.265
20716 SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 4.557 5.632
12768 CCR1 chemokine (C-C motif) receptor 1 4.501 4.698
12489 Cd33 CD33 antigen 4.368 4.975
23845 CLEC5A C-type lectin domain family 5, member A 4.148 4.047
12765 CXCR2 chemokine (C-X-C motif) receptor 2 4.125 5.535
100038947 Sirpb1a signal-regulatory protein beta 1A 3.944 3.915
83382 SIGLEC8 sialic acid binding Ig-like lectin 8 3.921 3.208
12273 C5AR1 complement component 5a receptor 1 3.893 2.917
16819 LCN2 lipocalin 2 3.862 3.671
16948 LOX lysyl oxidase 3.856 3.168
12986 CSF3R colony stimulating factor 3 receptor (granulocyte) 3.854 4.490
16409 ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.791 3.748
17395 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92 kDa type IV collagenase) 3.576 4.147
20308 CCL9 chemokine (C-C motif) ligand 9 3.551 2.835
246256 FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 3.511 3.572
74442 SGMS2 sphingomyelin synthase 2 3.491 2.318
11690 ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.466 3.410
170733 Klra17 killer cell lectin-like receptor, subfamily A, member 17 3.466 3.997
20568 SLPI secretory leukocyte peptidase inhibitor 3.433 2.644
18173 SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 3.212 2.344
56221 CCL24 chemokine (C-C motif) ligand 24 3.211 2.598
27226 PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 3.21 3.009
18733 LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.173 3.046
13058 CYBB cytochrome b-245, beta polypeptide 3.147 2.017
16176 IL1B interleukin 1, beta 3.147 2.196
170743 TLR7 toll-like receptor 7 3.136 2.434
278180 VSIG4 V-set and immunoglobulin domain containing 4 3.131 9.911
12978 CSF1R colony stimulating factor 1 receptor 3.076 2.409
19204 PTAFR platelet-activating factor receptor 3.049 2.502
21810 TGFBI transforming growth factor, beta-induced, 68kDa 3.004 2.992
20556 SLFN12L schlafen family member 12-like 3.001 2.139
12182 BST1 bone marrow stromal cell antigen 1 2.925 2.327
15368 HMOX1 heme oxygenase (decycling) 1 2.844 2.563
14293 FPR1 formyl peptide receptor 1 2.748 2.280
14191 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 2.675 2.150
57248 Ly6a lymphocyte antigen 6 complex, locus A 2.673 3.938
20351 SEMA4A sema domain, immunoglobulin domain, transmembrane domain and short cytoplasmic domain, 4A 2.654 2.315
74039 NFAM1 NFAT activating protein with ITAM motif 1 2.63 2.750
16854 LGALS3 lectin, galactoside-binding, soluble, 3 2.627 2.037
14131 FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.569 2.921
12267 C3AR1 complement component 3a receptor 1 2.546 3.573
14127 FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.529 2.279
80885 HCAR2 hydroxycarboxylic acid receptor 2 2.508 2.019
380924 OLFM4 olfactomedin 4 2.497 2.717
11801 CD5L CD5 molecule-like 2.492 5.669
12983 CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.444 2.262
16658 MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 2.428 2.510
22177 TYROBP TYRO protein tyrosine kinase binding protein 2.331 2.255
11501 ADAM8 ADAM metallopeptidase domain 8 2.327 2.410
170744 TLR8 toll-like receptor 8 2.177 2.221
378460 PRAM1 PML-RARA regulated adaptor molecule 1 2.153 2.739
20375 SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 2.142 2.175
14728 Gp49a/Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 2.007 2.302
18507 PAX5 paired box 5 −2.068 −2.522
14128 FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) −2.08 −3.552
12482 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 −2.130 −2.302
12478 CD19 CD19 molecule −2.183 −2.643
19695 Reg3g regenerating islet-derived 3 gamma −2.365 −2.158
15510 HSPD1 heat shock 60 kDa protein 1 (chaperonin) −2.529 −2.360
12517 CD72 CD72 molecule −2.539 −2.522
17888 MYH6 myosin, heavy chain 6, cardiac muscle, alpha −3.71 −2.284
230899 NPPA natriuretic peptide A −5.536 −5.525
15505 HSPH1 heat shock 105 kDa/110 kDa protein 1 −5.641 −3.651