Table 1. Biodistribution of radioactivity after intravenous administration of [125I]TAP1 in normal mice.
Time after injection (min) | |||||
5 | 15 | 30 | 60 | 120 | |
Blood | 3.25±0.20 | 3.91±0.75 | 3.45±0.41 | 2.02±0.35 | 1.72±0.49 |
Heart | 1.59±0.54 | 1.57±0.51 | 1.39±0.25 | 0.96±0.32 | 1.11±0.23 |
Lung | 3.12±1.11 | 2.88±0.65 | 2.76±0.49 | 1.93±0.91 | 1.46±0.13 |
Liver | 57.51±4.79 | 47.58±2.57 | 50.91±7.27 | 46.70±4.43 | 31.00±1.52 |
Kidney | 15.30±9.93 | 32.89±11.78 | 45.34±3.34 | 45.89±13.85 | 50.84±18.75 |
Intestine | 2.21±1.43 | 2.21±0.72 | 3.83±0.07 | 5.10±1.43 | 10.58±1.93 |
Stomacha | 0.40±0.14 | 0.76±0.14 | 0.92±0.21 | 1.40±0.69 | 2.02±0.70 |
Spleen | 1.54±0.60 | 1.84±0.43 | 1.29±0.13 | 1.14±0.38 | 1.44±1.21 |
Pancreas | 1.53±0.84 | 1.23±0.26 | 0.89±0.12 | 1.46±0.55 | 0.64±0.1 |
Muscle | 0.73±0.51 | 0.83±0.09 | 0.67±0.16 | 0.64±0.20 | 0.71±0.24 |
Thyroid glanda | 0.01±0.005 | 0.03±0.01 | 0.03±0.01 | 0.02±0.08 | 0.14±0.21 |
Data are presented as % injected dose per gram. Each value represents the mean±S.D. for 3 animals at each interval.
Presented as % injected dose per organ.