Table 1. Specificity of metastatic six gene signature.

Dataset	P-value of 6 gene signature	P-value relative to random sets
Affymetrix TCGA	0.004	0.001 (n = 10,729)
Agilent TCGA	0.0002	0.0008 (n = 10,054)
Australia	0.006	0.0025 (n = 10,000)

P-values are calculated by determining the number of random gene sets with lower p-values than the metastatic gene signature using the log-rank test of Kaplan Meier analysis divided by the number of random sets tested as indicated in parentheses.