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. 2014 Mar 27;111(14):E1383–E1392. doi: 10.1073/pnas.1402898111

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Fig. 4. — Inhibition of Notch and Fgf pathways is accompanied with cell cycle reentry immediately after hair cell ablation. (A, C, and D) In situ hybridization of Notch pathway, Fgf pathway, and cell cycle genes in 5-dpf untreated and neomycin-treated larvae. (A) The Notch pathway inhibitor numb is increased at 1 h after neomycin. The Notch target genes her4.1, notch3, and sox2 are decreased at 1 h and up-regulated at 3 h after neomycin treatment. atoh1a is up-regulated starting at 1 h after neomycin, and its target dld is increased at 5 and 10 h. (C) fgf3 and its target pea3 are down-regulated at 1 and 3 h after neomycin treatment. (D) Cell cycle inhibitory genes cdkn1b, cdkn1c, and rbl2 are decreased at 1 and 3 h after neomycin compared with control. (B and E) Heat maps of selected Notch pathway genes and cell cycle genes.