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. 2014 Mar 25;111(14):5409–5414. doi: 10.1073/pnas.1316510111

Fig. 1.

Fig. 1.

CX3CR1 mRNA-expressing cells are present within active lesions of the human MS brain. CX3CR1 expression within a representative, active MS lesion with dense aggregates of macrophages containing myelin breakdown products. (A) Immunostaining for CD68-detecting phagocytic microglia/macrophages. (B) In an adjacent section, increased numbers of microglia/macrophages filled with myelin-derived lipids are readily detected with oil red O staining, hence outlining the active region of the lesion. (D and E) This region also manifested high numbers of CX3CR1-expressing cells, although the highest expression (C) was demonstrated in the adjacent periplaque zone. Harris hematoxylin was used as counterstain.