Fig. 3.

p53 and E2F are major drivers of in vivo radiation response. (A) Transcription factors whose targets are most significantly enriched and depleted among translating mRNAs after IR. (B) Enrichment plots for targets of p53 and E2F. (C) Unsupervised hierarchical clustering of genes significantly altered by IR in PDGF and PDGF/p53shRNA gliomas. (D) Kaplan–Meier survival curves of unirradiated and irradiated PDGF/p53shRNA gliomas in Ink4a/Arf^−/− mice after postnatal day 18 randomization and single-dose 10-Gy IR. (E) Fold changes of the 50 most induced transcripts 6 h after 10-Gy IR in total RNA from PDGF-driven gliomas, and the corresponding fold change in total RNA from PDGF/p53shRNA tumors.