Table 1. Demographic, clinical and laboratory results of MDR suspects (n = 9).
N° | Status | Age | Sexe | Clinical History | N° of FLD course | Culture and DST on LJ in NRL Kinshasa | RpoB Sequencing at SRL in Antwerp | Treatment outcomes of SLD assessed in 2011 | ||||
SM | Culture | ID | RMP | INH | ||||||||
A | Case | 20 | F | F2 | 3 | + | + | MTBC | R | C | His526Tyr(TAC) | Treatment completed |
B | Case | 29 | M | F1 | 2 | ++ | + | MTBC | R | R | Ser531Trp(TGG) | Died |
C | Case | 31 | F | R2 | 3 | ++ | + | MTBC | R | R | Ser531Leu(TTG), Arg633Leu (CTC) | Cured |
D | Case | 38 | M | F2 | 3 | ++ | + | MTBC | S | R | His526Leu(CTC) | Died |
A1 | Contact | 6 | F | NA | NA | 0 | NG | NT | ||||
A2 | Contact | 22 | M | NA | NA | 0 | NG | NT | ||||
B1 | Contact | 59 | F | NA | NA | 0 | NG | NT | ||||
C1 | Contact | 24 | F | NA | NA | 0 | NG | NT | ||||
D1 | Contact | 41 | M | NA | NA | 0 | NG | NT |
A1: First contact of case A; A2: Second contact of case A; B1: First contact of case B; C1: First contact of case C; D1: First contact of case D. M: male; F: female. F1: Failure in WHO standard first line treatment regimen for category 1 for new cases; F2: Failure in WHO standard first line treatment regimen for category 2 retreatment cases; R2: Relapse in WHO standard first line treatment regimen for category 2 retreatment cases. NA: Not applicable. N° of FLD: Number of first-line drugs. SM: smear microscopy results. NG: no growth. ID: identification. MTBC: Mycobacterium tuberculosis complex. NT: not tested. R: Resistant; S: sensitive; C: contaminated. SLD: second-line drugs.