Table 4. Meta-analysis of COX-2 8473T>C polymorphism and CRC risk.
| Analysis | No. of studies | Homozygote (CC vs. TT) | Heterozygote (TC vs. TT) | Dominant model (CC+TC vs. TT) | Recessive model (CC vs. TC+TT) | ||||
| OR (95% CI) | P/P h | OR (95% CI) | P/P h | OR (95% CI) | P/P h | OR (95% CI) | P/P h | ||
| Overall | 8 | 0.948(0.843–1.066) | 0.369/0.824 | 1.008(0.934–1.088) | 0.841/0.969 | 0.995(0.926–1.070) | 0.899/0.988 | 0.941(0.842–1.051) | 0.284/0.713 |
| Ethnicity | |||||||||
| Caucasian | 8 | 0.948(0.843–1.066) | 0.369/0.824 | 1.008(0.934–1.088) | 0.841/0.969 | 0.995(0.926–1.070) | 0.899/0.988 | 0.941(0.842–1.051) | 0.284/0.713 |
| Cancer location | |||||||||
| Colon | 3 | 0.923(0.787–1.083) | 0.326/0.336 | 1.014(0.911–1.129) | 0.795/0.574 | 0.994(0.898–1.099) | 0.902/0.471 | 0.916(0.788–1.064) | 0.250/0.382 |
| Rectum | 2 | 0.946(0.726–1.233) | 0.682/0.554 | 1.020(0.861–1.208) | 0.823/0.748 | 1.005(0.855–1.180) | 0.955/0.642 | 0.937(0.729–1.203) | 0.609/0.606 |
| Source of control | |||||||||
| HB | 2 | 0.995(0.620–1.597) | 0.984/0.788 | 0.932(0.706–1.231) | 0.622/0.801 | 0.943(0.724–1.230) | 0.667/0.896 | 1.030(0.655–1.620) | 0.899/0.724 |
| PB | 6 | 0.945(0.837–1.066) | 0.356/0.626 | 1.014(0.937–1.098) | 0.727/0.921 | 1.000(0.927–1.077) | 0.950/0.992 | 0.936(0.835–1.049) | 0.255/0.510 |
P = P values for Z test. P h = P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies.