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. 2014 Apr 14;9(4):e94732. doi: 10.1371/journal.pone.0094732

Figure 2. CI decreases laminin degradation and attenuates I/R injury in the dog heart.

Figure 2

(a) Compared to the normal LV (left panel), I/R results in a decrease in the laminin staining in this border region (right panel). There is a greater increase in apoptotic cells (green) with loss of laminin. (b) CI treatment decreased I/R induced laminin degradation. (c) FAK dephosphorylation is markedly decreased in normal (NL) dog LV compared to I/R LV. CI treatment attenuated I/R induced p-FAK dephosphorylation. (d) CI pretreatment significantly attenuates the I/R-induced release of cTnI into the circulation. ** p<0.01. NL dog, n = 3; Veh dog, n = 6; CI dog, n = 5.