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. 2014 Apr 14;9(4):e94726. doi: 10.1371/journal.pone.0094726

Figure 8. Visceral hypersensitivity induced by NE.

Figure 8

(A) Application of NE (i.t.) significantly increased AWR scores in healthy control rats 30 min after intrathecal injection (n = 10, *p<0.05 vs. NS). (B) Application of NE significantly reduced distention threshold when tested 30 min after intrathecal injection (n = 10, *p<0.05 vs. NS). (C, D) The AWRs and distention threshold returned to normal level 60 min after the injection (n = 10 for each group). (E, F) Butoxamine administration (i.p.) blocked the effect of NE (i.t.) in healthy control rats (n = 5 for each group, *p<0.05 vs. NE+NS).