Table 2.

Co-primary measures of clinical effectiveness

Outcome	Definition
1. Risk domain asthma control; controlled or uncontrolled	Controlled if: • No asthma-related hospital attendance/admission,a • No GP consultations for LRTI,b and • No prescriptions for acute oral steroid courses
2. Exacerbation rate (ATS/ERS definition); number of exacerbations	Where exacerbation is an occurrence of: • Asthma-related hospital attendance/admissiona or • Use of acute oral steroids
3. Exacerbation rate (clinical definition); number of exacerbations	Where exacerbation is an occurrence of: • Asthma-related hospital attendance/admission,a • GP consult for LRTI,b or • Use of acute oral steroids
4. Overall asthma control; controlled or uncontrolled	Controlled if: • Risk domain asthma control, plus • Average prescribed SABA dosage ≤200 μg/day for salbutamol or ≤500 μg/day for terbutaline

Notes:

^aAsthma-related hospital attendance/admission included Accident and Emergency, out-of-hours, and outpatient departments;

^bconsultations for lower respiratory tract infections requiring antibiotic therapy.

Abbreviations: ATS/ERS, American Thoracic Society/European Respiratory Society; GP, general practitioner; LRTI, lower respiratory tract infection; SABA, short-acting β₂ receptor agonist