Table 2.

Bone mineral density changes after 12 months of subcutaneous denosumab 60 mg versus placebo in ADAMO (n=242 men)

	Denosumab	Placebo	P-value
ADAMO BMD changes from baseline
BMD lumbar spine	+5.7%	+0.9%	<0.0001
BMD total hip	+2.4%	+0.3%	<0.0001
BMD femoral neck	+2.1%	0.0%	<0.0001
BMD hip trochanter	+3.1%	+0.8%	<0.0001
BMD one third radius	+0.6%	−0.3%	<0.0144

Notes: Age, race, geographic region, previous osteoporotic fracture, baseline testosterone level, 10-year major osteoporotic fracture risk, and lumbar spine bone mineral density T-score did not confound the data and when controlled for separation from placebo and from baseline were still significant (P<0.0001 for each comparison).

Abbreviations: BMD, bone mineral density; ADAMO, Study to Compare the Efficacy and Safety of DenosumAb Versus Placebo in Males With Osteoporosis.