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. 2014 Apr 14;9(4):e95189. doi: 10.1371/journal.pone.0095189

Figure 6. Expression of regulators and signal transduction proteins show phase-specific behavior.

Figure 6

(A1-40 Four genes encoding nearly identical protein kinase-like proteins are down-regulated in WT-T variants. In each case, the PKc-like gene is downstream of a gene annotated as a serine-threonine protein kinase (S_T Pk). The PKc-like genes that share significant similarity with serine-threonine protein kinases. (A5) A putative kapC gene (KapC =  protein kinase associated protein) is down-regulated in WT-T. (A6–10) Expression of multiple S_T Pk-encoding genes and HTH-Xre-encoding genes (helix-turn-helix xenobiotic response element family of DNA-binding proteins) is increased in WT-T relative to WT-Y strains. Four colored boxes indicate genes whose products share sufficient identity to be considered a protein cluster (ci =  cluster index; NCBI protein cluster database PCLA designation). (B) The asgB mutant behaves similar to the WT-T with regard to genes in A, but differs from WT-T in that it also shows significant increases in four additional genes predicted to encode a S_T Pk, a hypothetical and two HTH-Xre proteins.