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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Comp Neurol. 2013 Oct 1;521(14):3217–3225. doi: 10.1002/cne.23341

Figure 1.

Figure 1

The CreER gene construct enables inducible excision of floxed gene sequence in adult facial motor neurons. Immunohistochemical localization of YFP reporter signal in the facial motor nucleus of an adult CreER+/YFP reporter+ mouse injected with tamoxifen 4 months prior to perfusion (A) and an age-matched, vehicle-injected CreER+/YFP reporter+ control (B). The YFP signal, indicating excision of floxed gene sequence, is found in roughly half of facial motor neurons following the induction of Cre activity, with the cells displaying a range of labeling intensity (A). The reporter signal was not observed in vehicle-injected controls (B). Images in (A,B) were identically captured and adjusted. The broken white line delineates the approximate borders of the facial motor nucleus. Scale bar = 100 µm.