Figure 3.
Adult-onset CNTFRα gene excision in facial motor neurons does not lead to loss of intact or axotomized motor neurons. CNTFRα-floxed mice and control mice were injected with tamoxifen at 3–4 months of age to induce Cre activity and received a unilateral facial nerve crush 4 months later. Four months after that they were perfused and the number of total (cresyl violet-stained) facial motor neurons ipsilateral and contralateral to the lesion were quantified. Two-way ANOVA analysis indicated there was no effect of lesion or CNTFRα gene excision and no interaction (P > 0.05 for all statistical comparisons). N = 9 CNTFRα-floxed mice; 11 control mice. Values are presented as mean ± SEM.