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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Comp Neurol. 2013 Oct 1;521(14):3217–3225. doi: 10.1002/cne.23341

Figure 4.

Figure 4

Adult-onset CNTFRα gene excision in facial motor neurons does not increase loss of motor neurons following penetrating injury of the facial motor nucleus. CNTFRα-floxed mice and control mice were injected with tamoxifen at 3–4 months of age to induce Cre activity and received a unilateral penetrating injury of the facial motor nucleus 4 months later. Four months after that they were perfused and the number of total (cresyl violet-stained) facial motor neurons ipsilateral and contralateral to the injury were quantified. The injury led to a small but significant overall decrease in the number of motor neurons. However, there was no interaction, indicating that the disruption of the CNTFRα gene did not increase motor neuron death. See text for complete description of statistical comparisons. N = 7 CNTFRα-floxed mice; 8 control mice. Values are presented as mean ± SEM.