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. 2014 Apr 14;9(4):e94885. doi: 10.1371/journal.pone.0094885

Figure 5. Nifedipine metabolism activity in HNF1α-transfected Hep G2 cells cultured for 7 days post-infection.

Figure 5

The metabolic activity was determined by measuring the levels of oxidized nifedipine. Oxidized nifedipine was quantified by HPLC-ESI-MS/MS. HH: human hepatocytes used as positive control. The nifedipine metabolism activities increased as viral MOI increased. The activity of the cells infected by control virus with MOI = 3,000 is similar to that in normal control cells (MOI = 0). *P<0.05, **P<0.01.