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. 2014 Apr 11;14:35. doi: 10.1186/1472-6823-14-35

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Copyright © 2014 Ma et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IGF parameters profiles. (a) Serum total IGF-I concentration, (b) bioactive IGF concentration, (c) IGFBP-1 concentration, *P < 0.01 as BIAsp50 compared with insulin aspart and human insulin for AUC_0–3; **P < 0.05, as BIAsp50 compared with human insulin for AUC_3–6; ***P < 0.05, as BIAsp70 compared with human insulin for AUC_0–9.(d) IGFBP-2 levels and (e) IGFBP-3 levels during 9-hour treatment with insulin aspart (open circles), BIAsp70 (black rectangles), BIAsp50 (open rectangles) and human insulin (black circles). For clarity, serum concentrations are illustrated as mean levels only.