Table 1.
Results of IGF parameters
| Parameter | Unit | Insulin aspart (a) | BIAsp70 (b) | BIAsp50 (c) | Human insulin (d) | p |
|---|---|---|---|---|---|---|
|
Total IGF-I |
|
|
|
|
|
|
| Baseline |
μg/l |
113 (109–117) |
121 (116–125) |
117 (113–121) |
115 (111–120) |
NS |
| Cmax |
μg/l |
124 (121–126) |
124 (122–126) |
122 (120–125) |
122 (119–124) |
NS |
| Cmin |
μg/l |
113 (111–114) |
113 (111–115) |
112 (110–114) |
113 (111–115) |
NS |
| AUC0-3 h |
μg*h/l |
353 (349–357) |
355 (351–359) |
353 (349–357) |
353 (350–357) |
NS |
| AUC3-6 h |
μg*h/l |
349 (337–362) |
370 (358–383) |
356 (344–369) |
352 (340–365) |
NS |
| AUC6-9 h |
μg*h/l |
346 (333–361) |
364 (352–378) |
351 (339–364) |
349 (336–362) |
NS |
| AUC0-9 h |
μg*h/l |
1071 (1053–1090) |
1071 (1055–1088) |
1059 (1043–1074) |
1064 (1048–1081) |
NS |
|
Bioactive IGF |
|
|
|
|
|
|
| Baseline |
μg/l |
0.60 (0.54-0.67) |
0.62 (0.56-0.69) |
0.68 (0.61-0.76) |
0.58 (0.52-0.65) |
NS |
| Cmax |
μg/l |
0.80 (0.76-0.84) |
0.79 (0.75-0.83) |
0.79 (0.75-0.84) |
0.82 (0.78-0.87) |
NS |
| Cmin |
μg/l |
0.46 (0.43-0.50) |
0.50 (0.47-0.54) |
0.52 (0.49-0.56) |
0.52 (0.48-0.56) |
NS |
| AUC0-3 h |
μg*h/l |
2.02 (1.96-2.09) |
1.96 (1.90-2.02) |
2.04 (1.98-2.11) |
2.08 (2.02-2.15) |
.051 |
| AUC3-6 h |
μg*h/l |
2.16 (2.02-2.31) |
2.11 (1.98-2.25) |
2.26 (2.11-2.41) |
2.27 (2.13-2.43) |
NS |
| AUC6-9 h |
μg*h/l |
1.82 (1.68-1.98) |
1.90 (1.76-2.05) |
1.99 (1.85-2.15) |
1.98 (1.83-2.14) |
NS |
| AUC0-9 h |
μg*h/l |
6.11 (5.80-6.45) |
5.98 (5.71-6.27) |
6.18 (5.89-6.49) |
6.43 (6.12-6.75) |
NS |
|
IGFBP-1 |
|
|
|
|
|
|
| Baseline |
μg/l |
130 (107–159) |
140 (115–171) |
116 (95–141) |
144 (118–176) |
NS |
| Cmin |
μg/l |
14 (11–18)c |
21 (16–27) |
26 (20–34)a |
22 (17–29) |
.009 |
| Tmin |
min |
259 (234–284) |
256 (231–280) |
231 (206–255) |
268 (244–293) |
NS |
| AUC0-3 h |
μg*h/l |
262 (233–294)c |
319 (284–359) |
351 (312–396)a,d |
256 (228–288)c |
.001 |
| AUC3-6 h |
μg*h/l |
112 (81–155) |
132 (96–183) |
164 (119–227)d |
83 (60–114)c |
.029 |
| AUC6-9 h |
μg*h/l |
662 (496–884) |
577 (445–747) |
455 (351–589) |
390 (298–510) |
NS |
| AUC0-9 h |
μg*h/l |
1092 (906–1317) |
1084 (917–1282)d |
1032 (871–1224) |
779 (654–927)b |
.025 |
|
IGFBP-2 |
|
|
|
|
|
|
| Baseline |
μg/l |
342 (312–375) |
356 (324–390) |
356 (325–391) |
380 (347–417) |
NS |
| Cmax 0-6 h |
μg/l |
477 (459–497) |
473 (455–493) |
462 (444–480) |
465 (447–485) |
NS |
| Tmax 0-6 h |
min |
215 (185–245) |
215 (185–245) |
218 (188–248) |
205 (175–235) |
NS |
| AUC0-3 h |
μg*h/l |
1225 (1191–1261) |
1224 (1189–1259) |
1184 (1151–1219) |
1212 (1177–1247) |
NS |
| AUC3-6 h |
μg*h/l |
1278 (1170–1395) |
1303 (1194–1423) |
1263 (1157–1378) |
1363 (1249–1488) |
NS |
| AUC6-9 h |
μg*h/l |
1127 (1015–1251) |
1261 (1149–1385) |
1221 (1112–1340) |
1247 (1132–1374) |
NS |
| AUC0-9 h |
μg*h/l |
3717 (3548–3892) |
3758 (3609–3916) |
3640 (3495–3792) |
3651 (3498–3813) |
NS |
|
IGFBP-3 |
|
|
|
|
|
|
| Baseline |
mg/l |
3.04 (2.97-3.11) |
3.12 (3.05-3.19) |
3.05 (2.97-3.12) |
3.01 (2.94-3.08) |
NS |
| Cmax |
mg/l |
3.30 (3.23-3.37) |
3.32 (3.25-3.39) |
3.30 (3.24-3.37) |
3.25 (3.18-3.32) |
NS |
| Cmin |
mg/l |
2.98 (2.94-3.02) |
3.00 (2.96-3.04) |
2.98 (2.94-3.02) |
2.99 (2.95-3.03) |
NS |
| AUC0-3 h |
mg*h/l |
9.23 (9.12-9.34) |
9.22 (9.11-9.33) |
9.23 (9.12-9.34) |
9.20 (9.09-9.31) |
NS |
| AUC3-6 h |
mg*h/l |
9.40 (9.16-9.66) |
9.67 (9.42-9.93) |
9.44 (9.19-9.69) |
9.26 (9.02-9.51) |
NS |
| AUC6-9 h |
mg*h/l |
9.45 (9.19-9.72) |
9.87 (9.63-10.12) |
9.60 (9.36-9.84) |
9.46 (9.22-9.71) |
NS |
| AUC0-9 h | mg*h/l | 28.19 (27.71-28.68) | 28.50 (28.05-28.94) | 28.33 (27.90-28.77) | 28.16 (27.71-28.61) | NS |
The results for Cmax, Cmin, Tmax, Tmin and AUCs are expressed as geometric mean (range) drawn from ANOVA. The outcomes were controlled for baseline levels (t = 0) if necessary, ap < 0.05 vs insulin aspart, bp < 0.05 vs BIAsp70, cp < 0.05 vs BIAsp50, dp < 0.05 vs human insulin.