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. 2014 Apr 8;6:63. doi: 10.3389/fnagi.2014.00063

Figure 2.

Figure 2

SCOP-induced temporary blackout of well-trained memory. (A–D) Rat performance tested after the injection of saline and various doses of SCOP or methyl-SCOP (0.02, 0.1, and 0.3 mg/kg). Rats never manipulated the lever 0.5 h after 0.10 or 0.30 mg/kg SCOP administration, as behavioral performance was unmeasurable (UM; B,C). In contrast, 0.02 mg/kg SCOP and all doses of methyl-SCOP did not affect performance (A,D). At 3 h after SCOP injection, rats remembered the task paradigm at 0.10 mg/kg and above (B,C), but the association between the lever and reward only at 0.30 mg/kg (C). (E,F) High concentration of SCOP (0.30 mg/kg) affects neither the amount of locomotor activity level measured in an open field nor the water intake from a regular water bottle. (G,H) SCOP injection at 0.30 mg/kg influenced anxiety. Data are presented as mean + SD; **P < 0.01. ***P < 0.001. n = 10 rats/group.