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. 2014 Apr 8;6:63. doi: 10.3389/fnagi.2014.00063

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Copyright © 2014 Soma, Suematsu and Shimegi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M1 AChR-mediated retrieval function of the 2AFC task. (A) A cholinesterase inhibitor, donepezil (1.0 mg/kg), was systemically administered to rats a half-hour before SCOP injection (0.30 mg/kg). Donepezil attenuated the effect of SCOP on the performance of the 2AFC task, as rats were able to recall the association between lever-manipulation and reward even 0.5 h after the SCOP injection and perform the 2AFC task after 3 h equally to that of the control condition. n = 5 rats/group. (B) DIC (8.0 mg/kg), an m1-specific AChR antagonist, was tested using the 2AFC task. The same effects as SCOP were seen, but in a shorter time course. n = 5 rats/group. (C) MEC, an nAChR antagonist, did not influence rat performance. n = 10 rats/group. Data are presented as mean + SD; ^**P < 0.01. ^***P < 0.001.