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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: J Periodontol. 2013 Jan 31;84(11):1606–1616. doi: 10.1902/jop.2013.120294

Figure 5.

Figure 5

Activity of luciferase reporter construct containing either unmodified or modified TNFA promoter fragment ranging from -291bp to +44bp relative to TSS. A) Cells transfected with pGL-3PTNFA291 construct showed increased luciferase activity upon induction by LPS as compared to uninduced construct. Lucfirase activity is relative to the empty vector. B) Cells transfected with in vitro methylated pGL-3PTNFA291Met showed a significantly decreased luciferase activity as compared to cells transfected with a mock methylated pGL-3PTNFA291Mo upon LPS induction (*p=0.03).