Table 4.
Hematological, clinical and radiation toxicities per patient (NCI/CTC) (ITT population, n = 70)
| |
Induction therapy (n =70), n (%) |
Consolidation therapy (n = 49), n (%) |
||
|---|---|---|---|---|
| All grades | Grade 3-4 | All grades | Grade 3-4 | |
|
Hematological toxicities per patient |
|
|
|
|
| Anemia |
36 (51.4) |
- |
39 (79.6) |
2 (4.1) |
| Neutropenia |
31 (44.3) |
17 (24.3) |
20 (40.8) |
1 (2) |
| Leukopenia |
27 (38.6) |
6 (8.6) |
30 (61.2) |
1 (2) |
| Thrombocytopenia |
15 (21.4) |
- |
11 (22.4) |
- |
| Febrile neutropenia (Pizzo) |
2 (2.85) |
- |
||
|
Clinical toxicities (NCI-CTC) |
|
|
|
|
| Fatigue |
31 (44.3) |
2 (2.9) |
23 (46.9) |
- |
| Nausea |
29 (41.4) |
1 (1.4) |
15 (30.6) |
1 (2) |
| Vomiting |
18 (25.7) |
2 (2.9) |
10 (20.4) |
1 (2) |
| Diarrhea |
11 (15.7) |
- |
5 (10.2) |
- |
| Constipation |
9 (12.9) |
- |
2 (4.1) |
- |
| Anorexia |
6 (8.6) |
- |
3 (6.1) |
1 (2) |
| Hypercreatininemia |
1 (1.4) |
- |
- |
- |
|
Radiation toxicities |
|
|
|
|
| Esophagitis |
- |
- |
13 (26.5) |
- |
| Skin injury |
- |
- |
12 (24.5) |
- |
| Dysphagia |
- |
- |
6 (12.2) |
- |
| Pain |
- |
- |
3 (6.1) |
|
| Pulmonary radiation injury |
- |
- |
1 (2) |
1 (2) |
| Radiation mucositis |
- |
- |
1 (2) |
- |
| Pneumonitis | - | - | 1 (2) | - |
Acute renal failure observed in 1 patient (G3 at induction).
Acute radiation pneumonitis at 30 days post-completion observed for 1 patient.