Table 4.
Breast density and subsequent breast cancer mortality in relation to mode of detection
| Rate of breast cancer deaths | HR 1 | HR 2 | HR 3 | HR 4 | |
|---|---|---|---|---|---|
|
All |
|
|
|
|
|
| Fatty |
7 of 93 |
1.00 |
1.00 |
1.00 |
1.00 |
| Moderate |
37 of 312 |
1.82 (0.81-4.08) |
1.80 (0.79-4.10) |
2.02 (0.87-4.67) |
2.09 (0.90-4.85) |
| Dense |
32 of 214 |
1.92 (0.85-4.35) |
2.24 (0.97-5.13) |
2.56 (1.07-6.11) |
2.63 (1.10-6.30) |
|
p-value for trend |
|
0.173 |
0.058 |
0.039 |
0.035 |
|
Non-symptomatic |
|
|
|
|
|
| Fatty |
3 of 50 |
1.00 |
1.00 |
1.00 |
– |
| Moderate |
13 of 183 |
1.37 (0.39-4.81) |
1.30 (0.36-4.76) |
1.40 (0.38-5.17) |
– |
| Dense |
11 of 117 |
1.47 (0.41-5.27) |
1.66 (0.43-6.41) |
2.04 (0.49-8.49) |
– |
|
p-value for trend |
|
0.586 |
0.427 |
0.293 |
– |
|
Symptomatic |
|
|
|
|
|
| Fatty |
4 of 43 |
1.00 |
1.00 |
1.00 |
– |
| Moderate |
24 of 129 |
2.43 (0.84-7.02) |
2.20 (0.74-6.51) |
2.62 (0.86-7.98) |
– |
| Dense |
21 of 97 |
2.33 (0.80-6.80) |
2.71 (0.91-8.06) |
3.40 (1.06-10.90) |
– |
| p-value for trend | 0.216 | 0.081 | 0.045 | – |
HR1: Crude.
HR2: Adjusted for diagnostic age (continuous), tumour size (mm), ALNI, grade, ER PgR and diagnostic period.
HR3 Adjusted for same factors as HR2 but also for HRT at diagnosis, BMI at baseline (continuous) and diagnostic period.
HR4: Adjusted for the same factors as HR3 but also for mode of detection (non-symptomatic or symptomatic).