Figure 1.

Flow diagram of the CAA consensus protocol process. A protocol was developed by CAA researchers using a modified Delphi method before being implemented by participants using images and sections of Aβ immunolabelled and H&E stained brain sections. The protocol was then validated by the assessment of 75 cases by 3 neuropathologists and inter-rater reliability determined. The results from the validation process were then used to investigate the relationship between APOE genotype, CAA severity and vasculopathy.