Figure 4.

Examples of CAA-associated vasculopathy. A. Fibrinoid necrosis, confirmed here by staining with phosphotungstic acid/haematoxylin. B. Thrombosis of a vessel shown in an adjacent section to contain Aβ. C. Micro-haemorrhage adjacent to a small amyloid-laden arteriole. D. Concentric splitting of the wall of amyloid-laden vessels (‘double-barrelling’). Sections are scored as zero if there is no vasculopathy, 1 if only occasional vessels are affected and 2 if many vessels are affected. The scale bars represent 100 μm in A and B, and 50 μm in C and D.